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Novel PET tracer detects small blood clots

Blood clots in veins and arteries can lead to heart attack, stroke, and pulmonary embolism, which are major causes of mortality. German researchers show that targeting GPIIb/IIIa receptors, the key receptor involved in platelet clumping, with a fluorine-18 (18F) labeled ligand is a promising approach for diagnostic imaging. Current imaging modalities rely on structural characteristics, such as vascular flow impairment, and do not address the critical molecular components. Read more.

Poor Sleep Tied to Alzheimer-Related Pathology

Sleep health may be target for early intervention

Self-reported poor sleep was associated with a greater presence of several cerebrospinal fluid (CSF) biomarkers of Alzheimer’s disease, according to a cross-sectional study.

Disrupted sleep or lack of sleep has previously been linked to a greater risk for brain amyloid plaque on PET imaging, but the study is among the first to show an association between poor sleep and amyloid and other biological markers for Alzheimer’s disease in the spinal fluid, wrote Barbara Bendlin, PhD, of the University of Wisconsin-Madison, and colleagues. Read more.

Comparative diagnostic accuracy of 18F-FDG PET/CT for breast cancer recurrence

Abstract

In the last decades, in addition to conventional imaging techniques and magnetic resonance imaging (MRI), 18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) has been shown to be relevant in the detection and management of breast cancer recurrence in doubtful cases in selected groups of patients. While there are no conclusive data indicating that imaging tests, including FDG PET/CT, produce a survival benefit in asymptomatic patients, FDG PET/CT can be useful for identifying the site of relapse when traditional imaging methods are equivocal or conflicting and for identifying or confirming isolated loco-regional relapse or isolated metastatic lesions. Read more.

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