Pretargeted PET imaging using a site-specifically labeled immunoconjugate

Abstract

In recent years, both site-specific bioconjugation techniques and bioorthogonal pretargeting strategies have emerged as exciting technologies with the potential to improve the safety and efficacy of antibody-based nuclear imaging. In the work at hand, we have combined these two approaches to create a pretargeted PET imaging strategy based on the rapid and bioorthogonal inverse electron demand Diels-Alder reaction between a 64Cu-labeled tetrazine radioligand (64Cu-Tz-SarAr) and a site-specifically modified huA33-trans-cyclooctene immunoconjugate (sshuA33-PEG12-TCO). Read more.

Tags: PET Research Abstracts

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